Opportunities

NTA provides a curated pipeline of vetted opportunities aligned with industry and national priorities.  We are continuously consolidating new opportunities from Catalyst Partners, government requirements, and industry targets. Contact us to share your opportunities with NTA’s diverse community or organizations.  Join NTA today to receive email notifications.

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Vaccines Capability Area

Vaccines Capability Area

Anticipated Release Date: Q3FY24 OR Q4FY24 Multiple Topics TBD—Possible 3 or 4 The goal of the Vaccines Capability Area is …
Accelerated Antibodies Modification

Accelerated Antibodies Modification

Anticipated Release Date: Q3FY24: Modification of existing Accelerated Antibodies agreement for additional monoclonal antibody prototype. Responding to this opportunity requires …
ChemDx Expansion

ChemDx Expansion

Anticipated Release Date: Q3FY24 Develop a diagnostic prototype strip, compatible with the ChemDx device, able to diagnose opioid exposure. Additional …
Development of Alternate Large Animal Models For Biothreats (Viral and Toxin) and Chemical Threats

Development of Alternate Large Animal Models For Biothreats (Viral and Toxin) and Chemical Threats

Anticipated Release Date: Q4FY24 Development of alternate large animal models for biothreats (viral and toxin) and chemical threats. Due to …
Prototype MCMs to address the therapeutic indications of the Warfighter exposure to viral and bacterial biothreat agents

Prototype MCMs to address the therapeutic indications of the Warfighter exposure to viral and bacterial biothreat agents

Anticipated Release Date: Q4FY24 The prioritizations on broad-spectrum direct-acting antivirals (nucleoside/nucleotide-like compounds and combination therapies) and host-directed broad-spectrum antivirals and …
Development of Novel, Broad Spectrum Countermeasures, and enabling capabilities for Toxin Exposure

Development of Novel, Broad Spectrum Countermeasures, and enabling capabilities for Toxin Exposure

Anticipated Release Date: Q4FY24 Prophylactic and therapeutic medical countermeasures for exposure to naturally occurring, synthetic and/or aerosolized toxins (excluding botulinum …
Mature Microphysiological System To Directly Compare To Well-Characterized Animal Model Results

Mature Microphysiological System To Directly Compare To Well-Characterized Animal Model Results

Anticipated Release Date: Q4FY24 Develop a microphysiological system that realistically mimics human physiological responses to threat exposures for rapid discovery …
Therapeutics Capability Area

Therapeutics Capability Area

Anticipated Release Date: Q3FY24 OR Q4FY24 Multiple Topics TBD—Possible 3 or 4 The goal of the Therapeutics Capability Area is …
Shipboard Isolation System (SIS) / PPMT

Shipboard Isolation System (SIS) / PPMT

Anticipated Release Date: Q4FY24 The SIS program provides the capability to temporarily isolate or quarantine personnel to prevent the spread …
Portable Patient Transport System -Enhanced Biodefense (PPTS-ENBD) / PPMT

Portable Patient Transport System -Enhanced Biodefense (PPTS-ENBD) / PPMT

Anticipated Release Date: Q4FY24 The Portable Patient Transport System Enhanced Biodefense (PPTS ENBD) is a patient transport system that enables …
IEW Phase 2 

IEW Phase 2 

Anticipated Release Date: Q4FY24 Establish Mission Planning and integration of the tactical, operational, Network convergence and CI/CD pipeline. This will allow …
Consolidated Nerve Agent Treatment System

Consolidated Nerve Agent Treatment System

Anticipated Release Date: Q1FY25 FDA approval of a multi-drug autoinjector to reduce logistical burden on the warfighter and increase survivability …
Agent Directed Therapeutic (ADTX) FY25 OTA

Agent Directed Therapeutic (ADTX) FY25 OTA

Anticipated Release Date: Q1FY25 New start OTA award for ADTX Responding to this opportunity requires membership in the Countering Weapons …
Autonomous Decontamination System (ADS) / PPMT 

Autonomous Decontamination System (ADS) / PPMT 

Anticipated Release Date: Q1FY25 The Autonomous Decontamination System program will provide a semi-autonomous supported capability that relies on precision detection …
VADER VaporAgent Demasking –Easily Readable

VADER VaporAgent Demasking –Easily Readable

Anticipated Release Date: Q2FY25 VaporAgent Demasking –Easily Readable Develop low-burden, low-cost detection capabilities for chemical threat vapors to facilitate doffing …
Novelbioaerosol Detection and Identification Technologies

Novelbioaerosol Detection and Identification Technologies

Anticipated Release Date: Q2FY25 Novel approaches to bioaerosol detection and identification that implement reliable, accurate and timely sampling mechanisms in a …
Diagnostic Platforms for Agnostictoxin Detections

Diagnostic Platforms for Agnostictoxin Detections

Anticipated Release Date: Q2FY25 Develop diagnostic and detection assays, platforms, or devices to sense exposures of emerging toxins, to include …
Portable Patient Transport System – Enhanced Biodefense, PPTS-ENBD

Portable Patient Transport System – Enhanced Biodefense, PPTS-ENBD

Anticipated Release Date: Q3FY25 PPTS-ENBD will provide a biocontainment isolation system to safely transport personnel infected or suspected of infection …
Shipboard Isolation System (SIS)

Shipboard Isolation System (SIS)

Anticipated Release Date: Q3FY25 SIS will provide the capability to temporarily isolate or quarantine personnel to prevent the spread of …
Biocontainment Isolation System - Enhanced Biodefense (BCIS-ENBD)

Biocontainment Isolation System – Enhanced Biodefense (BCIS-ENBD)

Anticipated Release: Q3FY25 BCIS-ENBD will provide a ground-based isolation area for personnel infected or suspected of infection of biological organism …
Synthetic Binder Prediction, Synthesis, and Assay Development

Synthetic Binder Prediction, Synthesis, and Assay Development

Anticipated Release: Q3FY25 This effort will solicit multidisciplinary teams for a competition involving prediction of synthetic binders, synthesis of identified …
Capabilities and Needs for Future Respiratory and Ocular Protection Systems

Capabilities and Needs for Future Respiratory and Ocular Protection Systems

Anticipated Release Date: Q3FY25 This topic aims to provide novel, low-burden masks for the general purpose warfighter utilizing innovative materials …
CIND, All States of Matters For Various Chemical Hazards

CIND, All States of Matters For Various Chemical Hazards

Anticipated Release: Q4FY25 Chemical indicators; Low-cost, easy to use, ultra-low SWaP modular open system based chemical detector that is widely …
CBRN Sensor Integration On Robotic Platforms (CSIRP) Capability Set (CS) 4.0

CBRN Sensor Integration On Robotic Platforms (CSIRP) Capability Set (CS) 4.0

Anticipated Release: Q4FY25 The Government is seeking proposals for development and integration of new CBRN sensing payloads, using common interfaces, …
Far Forward Biological Sequencing (FFBS), Increment 2

Far Forward Biological Sequencing (FFBS), Increment 2

Anticipated Release: Q1FY26 FFBS Increment 2 will focus on automating the sample preparation process and meeting any key performance parameter …
Advanced System for Protection and Integrated Reduction of Encumbrances, ASPIRE

Advanced System for Protection and Integrated Reduction of Encumbrances, ASPIRE

Anticipated Release Date: Q3FY26 ASPIRE will provide respiratory and ocular protection against Chemical, Biological, Radiological and Nuclear threats that allows …
Advanced Differential Diagnostics (ADD)

Advanced Differential Diagnostics (ADD)

Anticipated Release: Q4FY27 Host response based test to predict illness severity. Responding to this opportunity requires membership in the Countering …

Active

Algorithms for Threat Detection

Algorithms for Threat Detection

Due: February 19, 2025 The Algorithms for Threat Detection (ATD) program will support research projects to develop the next generation …
Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods

Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods

Due: February 19, 2025 The purpose of this notice of funding opportunity (NOFO) is to encourage applications from Small Business …
Climate Resilience Centers

Climate Resilience Centers

Due: February 20, 2025 The DOE SC program in Biological and Environmental Research (BER) hereby announces its interest in applications …
Enabling Discovery through GEnomics

Enabling Discovery through GEnomics

Due: February 20, 2025 Through the Enabling Discovery through GEnomics (EDGE) program, the National Science Foundation (NSF) and the National …
Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders

Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders

Due: February 24, 2025 This funding opportunity announcement strives to contribute to the emergence of new solutions by seeking applications …
Lactose Polymerization Technologies

Lactose Polymerization Technologies

Due: February 26, 2025 A multi-billion-dollar global food and beverage company seeks innovative technologies for converting lactose into a dairy-based …
Medical Devices for Pediatric Population Affected by Substance Use and Addiction

Medical Devices for Pediatric Population Affected by Substance Use and Addiction

Due: February 26, 2025 This notice of funding opportunity (NOFO) invites Small Business Innovation Research (SBIR) grant applications from small …
Atmospheric System Research (ASR)

Atmospheric System Research (ASR)

Due: February 27, 2025 The DOE SC program in Biological and Environmental Research (BER) hereby announces its interest in receiving …
Energy Improvements in Rural or Remote Areas - Fiscal Year 2025 Release

Energy Improvements in Rural or Remote Areas – Fiscal Year 2025 Release

Due: February 27, 2025 Rural and remote areas often have higher energy costs and burden, less resilient energy systems, and …
Human Virome Program: Developing novel and innovative tools to interrogate and annotate the human virome

Human Virome Program: Developing novel and innovative tools to interrogate and annotate the human virome

Due: February 27, 2025 The Common Fund Human Virome Program aims to extensively characterize the human virome and create tools, …
2025 Space Innovation Challenge

2025 Space Innovation Challenge

Due: March 1, 2025 The future of space exploration and commercialization demands cutting-edge technology to support the next generation of …
Smart Cities Smart Bases Innovation Challenge

Smart Cities Smart Bases Innovation Challenge

Due: March 1, 2025 The Smart Cities Smart Bases Innovation Challenge is looking for you to deliver cutting-edge, dual-use technologies that address …
Civic Innovation Challenge

Civic Innovation Challenge

Due: March 3, 2025 The Civic Innovation Challenge (CIVIC) is a research and action competition that accelerates the transition to …
Coupling, Energetics, and Dynamics of Atmospheric Regions

Coupling, Energetics, and Dynamics of Atmospheric Regions

Due: March 5, 2025 The Coupling, Energetics, and Dynamics of Atmospheric Regions (CEDAR) program supports research to increase our understanding …
TechConnect Critical Technology Challenge: Energy

TechConnect Critical Technology Challenge: Energy

Due: March 7, 2025 The TechConnect Critical Technology Challenge: Energy is a premier open innovation program designed to accelerate solutions …
TechConnect Critical Technology Challenge: Electronics and Microsystems

TechConnect Critical Technology Challenge: Electronics and Microsystems

Due: March 7, 2025 The TechConnect Critical Technology Challenge: Electronics and Microsystems is a premier open innovation program designed to …
TechConnect Critical Technology Challenge: Biotech And Medical

TechConnect Critical Technology Challenge: Biotech And Medical

Due: March 7, 2025 The TechConnect Critical Technology Challenge: Biotech and Medical is a premier open innovation program designed to …
TechConnect Critical Technology Challenge: AI and Digital Transformation

TechConnect Critical Technology Challenge: AI and Digital Transformation

Due: March 7, 2025 The TechConnect Critical Technology Challenge: Artificial Intelligence is a premier open innovation program designed to accelerate …
Critical Technology Challenge: Advanced Materials and Manufacturing

Critical Technology Challenge: Advanced Materials and Manufacturing

Due: March 7, 2025 The TechConnect Critical Technology Challenge: Advanced Materials & Manufacturing is a premier open innovation program designed …
In Vivo Non-Invasive Optical Imaging Approaches for Biological Systems

In Vivo Non-Invasive Optical Imaging Approaches for Biological Systems

Due: March 7, 2025 The purpose of the Advancing Non-Invasive Optical Imaging Approaches for Biological Systems initiative is to overcome …
TechConnect World Innovation Challenge

TechConnect World Innovation Challenge

Due: March 7, 2025 Launch your electrifying journey into the future of innovation! Join the world’s largest multi-sector commercialization program …
WaterSMART Environmental Water Resources Projects 2024

WaterSMART Environmental Water Resources Projects 2024

Due: March 11, 2025 The United States Department of the Interior’s (DOI’s) WaterSMART (Sustain and Manage America’s Resources for Tomorrow) …
High-Assay Low-Enriched Uranium (HALEU) Nuclear Fuel Supply Chain Innovative Technology Notice of Funding Opportunity

High-Assay Low-Enriched Uranium (HALEU) Nuclear Fuel Supply Chain Innovative Technology Notice of Funding Opportunity

Due: March 12, 2025 High-Assay Low-Enriched Uranium (HALEU) Nuclear Fuel Supply Chain Innovative Technology Notice of Funding Opportunity: This Notice …
High Performance PPE for Extreme Environments

High Performance PPE for Extreme Environments

Due: March 13, 2025 ABSTRACT TechConnect’s client seeks to enhance the comfort and effectiveness of its workers by identifying next-generation …
Environmental System Science (ESS)

Environmental System Science (ESS)

Due: March 13, 2025 The DOE SC program in Biological and Environmental Research (BER) hereby announces its interest in receiving …
Targeting Inflammasomes in HIV and Substance Use

Targeting Inflammasomes in HIV and Substance Use

Due: March 13, 2025 The scientific objective of this Funding Opportunity Announcement is to encourage research to delineate the role …
Great Lakes Fish Monitoring and Surveillance Program

Great Lakes Fish Monitoring and Surveillance Program

Due: March 14, 2025 The Great Lakes Fish Monitoring and Surveillance Program (GLFMSP) helps EPA satisfy statutory requirements under section …
2025 MOSA Innovation Challenge

2025 MOSA Innovation Challenge

Due: March 14, 2025 Twenty-first century air mobility requires 21st century technology. Attend the Challenge and watch more than 20 …
Scalable Solutions Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health

Scalable Solutions Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health

Due: March 14, 2025 This ISO seeks solution summaries and proposals for projects that fall within the general scope of …
2025 High Throughput, Small Volume Injection Technology Sprint

2025 High Throughput, Small Volume Injection Technology Sprint

Due: March 13, 2025 ABSTRACT TechConnect’s client seeks technology to rapidly inject small volumes of liquid into a rubbery polymer …
Experts in Encapsulation for Low pH Applications Sprint

Experts in Encapsulation for Low pH Applications Sprint

Deadline: March 14, 2025 ABSTRACT Our client, a global beverage company, seeks experts in encapsulation technologies. The client is interested …
Mathematical Foundations of Digital Twins

Mathematical Foundations of Digital Twins

Due: March 17, 2025 The Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS) at …
Mathematical Foundations of Digital Twins

Mathematical Foundations of Digital Twins

Due: March 17, 2025 The Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS) at …
Expeditions in Computing

Expeditions in Computing

Due: March 26, 2025 The far-reaching impact and rate of innovation in the computer and information science and engineering fields …
Combating Antibiotic-Resistant Bacteria Interdisciplinary Research Units (CARBIRUs)

Combating Antibiotic-Resistant Bacteria Interdisciplinary Research Units (CARBIRUs)

Due: March 26, 2025 The purpose of this notice of funding opportunity (NOFO) is to support multidisciplinary research programs focused …
Expeditions in Computing

Expeditions in Computing

Due: March 31, 2025 The far-reaching impact and rate of innovation in the computer and information science and engineering fields …
NSF National Quantum Virtual Laboratory - Quantum Testbeds

NSF National Quantum Virtual Laboratory – Quantum Testbeds

Due: April 1, 2025 With this program solicitation, the National Science Foundation is taking the next step in implementing the …
NSF National Quantum Virtual Laboratory - Quantum Testbeds

NSF National Quantum Virtual Laboratory – Quantum Testbeds

Due: April 1, 2025 The National Quantum Initiative (NQI) Act1aims to ensure the continuing leadership of the United States (U.S.) …
NUCLEAR SCIENCE AND ENGINEERING CONSORTIUM FOR NONPROLIFERATION

NUCLEAR SCIENCE AND ENGINEERING CONSORTIUM FOR NONPROLIFERATION

Due: April 4, 2025 The U.S. Department of Energy, National Nuclear Security Administration (DOE/NNSA), Office of Defense Nuclear Nonproliferation Research …
Department of Army Energetics Basic Research Center (EBRC) Fiscal Year 2025

Department of Army Energetics Basic Research Center (EBRC) Fiscal Year 2025

Due: April 7, 2025 The future Army is projected to be unable to achieve dominance in range and lethality due …
NSF/CASIS Transport Phenomena Research at the International Space Station to Benefit Life on Earth

NSF/CASIS Transport Phenomena Research at the International Space Station to Benefit Life on Earth

Due: April 10, 2025 The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) and the Division of Civil, Mechanical, …
Health Security Innovation Challenge

Health Security Innovation Challenge

Due: April 16, 2025 About Advancing Next-Generation Solutions for Prevention, Protection and Rapid Response As global health threats continue to …
Regional Partnerships for Geothermal Data

Regional Partnerships for Geothermal Data

Due: April 22, 2025ConnectWerx, a Partnership Intermediary of the U.S. Department of Energy (DOE) offers a funding opportunity in collaboration …
Collaborations Advancing Rapid Load Additions (CARLA)

Collaborations Advancing Rapid Load Additions (CARLA)

Due: April 24, 2025 5 PM ET ConnectWerx, a Partnership Intermediary under a  Partnership Intermediary Agreement (PIA) of the U.S …
Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications

Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications

April 25, 2025 This Notice of Funding Opportunity Announcement (NOFO), issued by the National Institutes of Health (NIH) and the …
Industrialization and Translation of Extracellular Vesicles For Use In Regenerative Medicine

Industrialization and Translation of Extracellular Vesicles For Use In Regenerative Medicine

DUE: June 7, 2025 STTR Opportunity: Supporting the development of extracellular vesicle technologies for regenerative medical applications APPLY …
Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

DUE: June 25, 2025 SBIR Opportunity: Supporting the development of extracellular vesicle technologies for regenerative medical applications. APPLY …
Cybersecurity Innovation for Cyberinfrastructure

Cybersecurity Innovation for Cyberinfrastructure

Due: April 2, 2025 The objective of the Cybersecurity Innovation for Cyberinfrastructure (CICI) program is to advance scientific discovery and …
Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products

Due: July 14, 2026 This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase …
Grant Opportunity: Research Projects to Enhance Applicability of Mammalian Models for Translational Research

Grant Opportunity: Research Projects to Enhance Applicability of Mammalian Models for Translational Research

DUE: September 7, 2026 The National Cancer Institute invites applications for projects to expand, improve, or transform the utility of …
Grant Opportunity: Assay development and screening for discovery of chemical probes, drugs or immunomodulators

Grant Opportunity: Assay development and screening for discovery of chemical probes, drugs or immunomodulators

DUE: September 7, 2026 Seeking applications for identification of small molecules that function to elucidate the biology of disease as …
Grant Opportunity: Personal Health Informatics for Delivering Actionable Insights to Individuals

Grant Opportunity: Personal Health Informatics for Delivering Actionable Insights to Individuals

DUE: November 5, 2026 Furthering the science of personal health informatics by providing meaningful and actionable insights to individuals through …
Grant Opportunity: Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics

Grant Opportunity: Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics

DUE: January 7, 2027 Funding available to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics …
Grant Opportunity: Improving Diagnostic Safety in Ambulatory Care

Grant Opportunity: Improving Diagnostic Safety in Ambulatory Care

DUE: August 31, 2028 Funding opportunity to develop strategies and interventions to improve diagnostic safety in the heterogenous ambulatory care …
AHRQ Health Services Research Projects

AHRQ Health Services Research Projects

Due: October 6, 2029 The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant …