Due: March 10, 2026
This notice of funding opportunity (NOFO) invites applications to investigate protective and pathogenic mechanisms at the nexus of mitochondrial function and aging in the context of HIV infection, ART and exposure to addictive substances. Basic and preclinical research projects are appropriate. Substances of interest include, but not limited to: synthetic and non-synthetic opioids, nicotine, cocaine, methamphetamine, other stimulants, psychedelics, xylazine, addictive prescription drugs, cannabinoids, or combinations of these substances. We anticipate this foundational knowledge could be leveraged to develop targeted therapies and improve outcomes in people aging with HIV, substance use and addiction.