Due: October 20, 2025
This notice of funding opportunity (NOFO) invites applications that propose interdisciplinary research that aims to develop complex mammalian 3-dimensional (3D)in vitromicrophysiological systems (MPS) to model aging and recapitulate aging processes/phenotypes observed in the whole organismin vivo. This NOFO is primarily focused on human cell-derived MPS (e.g., tissue chip, organ-on-chip, tissue organoids). However, systems developed using cells of nonhuman mammalian origin are acceptable for benchmarking, system validation, or when their relevance to understanding human aging biology is justified. Supported projects will be expected to advance the adoption of MPS in aging biology research and as new human-relevant tools for drug discovery.